What Happens If You Don't Eat for 3 Days? - Part IV
The Big Health Secrets You're Not Supposed To Know
72-Hour Fast: Regeneration and Rejuvenation of Hematopoietic Stem Cells
After 72 hours of fasting, significant regeneration and rejuvenation of hematopoietic stem cells (HSCs) occurs as the body undergoes a metabolic switch. During this phase, cells transition to utilizing fat as their primary energy source, which enhances the regenerative capacity of HSCs. These immature cells can differentiate into various cell types, serving as a vital repair mechanism for the body by replacing damaged tissues and organs.
Aging can induce genetic changes in HSCs, leading to a decline in their regenerative capabilities. This results in decreased potency, self-renewal, and regeneration of stem cells. However, prolonged fasting has been shown to stimulate the regeneration of HSCs. After three days of fasting, the production of new and improved stem cells can significantly rejuvenate aging cells. This regenerative process continues until normal eating resumes.
To maximize the benefits of HSC regeneration, individuals may choose to extend fasting to five to seven days, achieving a comprehensive reset of the body. Extended fasting has demonstrated potential anti-aging effects, alleviates chronic disease conditions, and may help relieve pain and stiffness in joints caused by previous injuries.
Athletes, in particular, often invest significantly in stem cell injections for joint, skin, and injury repair. Prolonged fasting can provide similar regenerative benefits without the associated risks of injections.
Protection from Chemotherapy-Induced Damage
Fasting can enhance the effectiveness of chemotherapy by increasing the sensitivity of cancer cells to antineoplastic drugs, making it easier for these cancer cells to be eliminated compared to normal cells. Research has shown that fasting leads to significant reductions in blood glucose, insulin, and insulin-like growth factor 1 (IGF-1) level, which create a negative environment for cancer cells proliferation.
A clinical trial involving 34 patients with breast or ovarian cancer undergoing chemotherapy demonstrated promising results. Patients began fasting mimicking diet 36 hours prior to chemotherapy and continued for 24 hours post-treatment. The fasting diet was limited to 350 kcal per day consisting of tea, vegetable juices and broth. Half of the patients fasted in the initial phase of chemo and the other half fasted in the final stage.
Participants reported only minor side effects such as headaches and nausea, which did not interfere with daily activities. Weight loss and reductions in body mass index were minimal.
Notably, those who fasted during the initial chemotherapy phase experienced improvements in quality of life and reduced fatigue. Detrimental effects on healthy and fast growing cells such as blood cells, hair follicles or reproductive organs are unavoidable during chemotherapy. At the end of the study, most cells resumed normal function and new cells regenerated.
Fasting appeared to mitigate the adverse effects of chemotherapy while enhancing its efficacy. Animal studies have further demonstrated that fasting cycles can activate hematopoietic stem cells, regenerate immune cells, and support gut health, all of which contribute to improved cancer outcomes.
Deep Autophagy
Deep autophagy, or extensive autophagy, is a heightened state of cellular cleanup that occurs during prolonged fasting. At the 72-hour mark, autophagy becomes more intense, involving not just the degradation of damaged cellular components but also the recycling of entire organelles like mitochondria and ribosomes.
This process enhances the removal of damaged materials, promotes cellular renewal, and improves adaptability to nutrient scarcity, ultimately supporting cell survival and longevity. Additionally, deep autophagy helps eliminate cancer-promoting cells and reduces tumor growth.
Mitophagy
Mitophagy is a specific form of autophagy targeting damaged mitochondria, which can suffer from oxidative stress, mutations, or excessive reactive oxygen species production. Mitochondria is a powerhouse for energy production.
Mitophagy plays an essential role in maintaining cellular health by removing dysfunctional mitochondria, thereby preventing oxidative damage and supporting cellular energy production. This process is beneficial for neurons, reducing the risk of neurodegenerative diseases.
Ribophagy
Ribophagy is a selective autophagic process focused on degrading ribosomes, the cellular machinery responsible for protein and DNA synthesis. This process is activated in response to starvation or mTOR pathway inhibition. While mTOR is essential for cellular growth and proliferation, its overactivation is linked to various health issues, including diabetes, obesity, depression, neurodegenerative disorders, and tumor growth.
Immune System Reboot
Prolonged fasting can lead to the regeneration of immune cells, including white blood cells which are crucial for combating infections. Fasting promotes a redistribution of circulating immune cells to the bone marrow, where they can be replenished. In addition, fasting can help alleviate autoimmune diseases by promoting the repair of the gut lining, which prevent conditions such as leaky gut.
The potential of prolonged fasting is significant, and in the upcoming discussion next week, we will explore the various fasting methods one should implement.
If you find this information helpful, please share with your friends and family who may benefit from this information.
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