5 Simple Ways to Manage Rheumatoid Arthritis Naturally - Part III
The Rheumatoid Arthritis Secrets You're Not Supposed To Know
Probiotics
Probiotics are live microorganisms that provide health benefits when consumed in adequate amounts. They’re often referred to as "good" or "friendly" bacteria because they help maintain a healthy balance of microorganisms in your gut.
Probiotics are commonly found in fermented foods like yogurt, kefir, sauerkraut, kimchi, and miso, as well as in dietary supplements. They can support digestive health by aiding in the balance of gut flora and enhancing the immune system.
Immune System Modulation
Probiotics may help modulate the immune system by promoting a balanced immune response. They can influence the activity of immune cells and the production of cytokines (signaling molecules in the immune system), potentially reducing the overactive immune responses characteristic of autoimmune conditions.
Probiotics may affect Toll-like receptors, which are involved in recognizing pathogens and initiating immune responses. Proper TLR activation can help in maintaining immune system balance and preventing inappropriate immune responses.
Gut Barrier Function
Probiotics help maintain the integrity of the gut lining, which is crucial for preventing "leaky gut" syndrome. In autoimmune diseases, a compromised gut barrier can allow harmful substances to enter the bloodstream, potentially triggering or exacerbating autoimmune reactions.
Regulation of Inflammation
Probiotics can influence inflammation levels in the body. They may help reduce systemic inflammation, which is often elevated in autoimmune conditions. By promoting a healthy balance of gut microbiota, probiotics may help control inflammatory responses.
Modulation of Gut Microbiota
Imbalances in gut microbiota have been linked to various autoimmune diseases. Probiotics can help restore a healthy balance of gut bacteria, which might positively impact autoimmune disease progression or symptoms
Colostrum
Colostrum is the first milk produced by mammals in the first few days after birth. The first milk is different from milk secreted later, colostrum is rich in antibodies and provides crucial immunity protection and helps to build the digestion system for the newborn. It lasts for two to four days after lactation is started.
The first milk after birth is rich in immunoglobulin (Ig), antimicrobial peptides, growth factors, macronutrients such as proteins and fat and micronutrients like vitamins and minerals which are essential for nutrition, growth and development.
Colostrum is often referred as “liquid gold” because of its high nutritional value and played a crucial role in laying the foundation of newborn’s immune and gastrointestinal system.
Autoimmune Disease/ Leaky Gut Syndrome
Colostrum contains growth factors such as EGF (Epithelial Growth Factor) and TGF (Transforming Growth Factor) that promote the repair and regeneration of the gut lining. These factors help maintain the integrity of the epithelial cells that form the gut barrier, reducing intestinal permeability and preventing leaky gut.
Colostrum assists in repairing the intestinal lining, which is essential for preventing the leakage of undigested food particles and toxins into the bloodstream.
Oligosaccharides in colostrum act as prebiotics, encouraging the growth of beneficial gut bacteria, which can improve digestion and contribute to overall gut health.
Anti-Inflammatory Properties
Colostrum’s growth factors and cytokines help modulate immune responses and reduce inflammation, which can be beneficial in healing tissues and managing inflammatory conditions.
Besides anti-bacteria, anti-viral and anti-cancer activity, lactoferrin also has anti-inflammatory property. Lactoferrin receptors have been identified on immune cells and is responsible for releasing cytokines. Cytokines are interleukines which regulates the duration and the intensity of the immune response. Lactoferrin helps restore the homeostatsis of the immune system.
What did the research say?
Probiotics
In a randomized double-blind clinical trials, sixty female patients with rheumatoid arthritis (RA) were randomized to receive probiotics versus the placebo for 8 weeks. The probiotic group had decreased serum C-reactive protein as well as decreased in tender and swollen joints. There was a significant difference in inflammatory cytokines between the two groups. The authors concluded that probiotic supplementation may be an appropriate adjunct therapy for RA patients.
Another randomized double-blind controlled trial was conducted to determine the effects of probiotic supplementation on patients with RA. Sixty patients with RA were assigned into probiotic and placebo group for 8 weeks.
At the end of the study, the probiotic group had improvement in Disease Activity Score of 28 joints. There was a significant decrease in serum insulin levels and C-reactive proteins for the probiotic group.
Colostrum
A systematic review analysis evaluated the effectiveness of bovine colostrum supplementation for leaky gut syndrome in athletes. Research showed that vigorous exercise increased intestinal permeability and bovine colostrum supplementation helped to reverse gut permeability in athletes.
The authors concluded that bovine colostrum supplementation may be highly beneficial in improving gut permeability in athletes but a larger well-designed studies are needed to evaluate the long-term safety and efficacy.
A meta-analysis of randomized clinical trials was conducted to analyze the impact of bovine colostrum on the gut permeability The study concluded that bovine colostrum supplementation significantly reduced intestinal permeability. However, further studies are needed to determine the dose and duration of the therapy.
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These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition