The untold truth about salt and hypertension
We always hear that salt causes hypertension and doctors suggest to cut back on sodium intake.
Salt does not cause hypertension, it is the sugary food and highly processed carbohydrates that cause elevated glucose level in the body. With prolonged high glucose level, the body develops insulin resistance.
Insulin resistance is the root cause of the problem.
What is insulin resistance?
Insulin resistance is a condition in which the body's cells become less responsive to the hormone insulin, resulting in impaired glucose uptake from the bloodstream into cells.
When cells become resistant to insulin, they require higher levels of insulin to respond, leading to elevated insulin levels in the bloodstream.
How does insulin resistance affect blood pressure?
Impaired kidneys function
Insulin resistance is associated with impaired kidney function which reduced sensitivity to insulin’s effect on sodium excretion. Therefore, the kidneys retain more sodium, leading to increased blood volume and blood pressure.
“Fight or flight” System
Insulin resistance also triggers the sympathetic nervous system. The sympathetic nervous system is responsible for the body's "fight or flight" response, mobilizing the body's resources to deal with stress or danger.
Activation of the sympathetic nervous system leads to increased heart rate, increased force of heart contractions, and constriction of blood vessels in non-essential organs such as the skin and digestive system. These effects help increase blood pressure and redirect blood flow to tissues that need it most during times of stress.
Impaired Nitric Oxide Production
Nitric oxide acts as a vasodilator, meaning relaxes the inner muscles of blood vessels, causing them to widen. This improves blood flow throughout the body.
Insulin resistance impairs nitric oxide production, leading to blood vessel constriction and increased blood pressure. Insulin is important for regulating blood pressure and maintain cardiovascular health.
Nitric oxide is produced naturally by the body's cells, and its levels can be influenced by diet and lifestyle factors.
Simple Ways to reduce insulin resistance
Healthy Diet
Adopting a balanced and nutritious diet can help improve insulin sensitivity. Focus on whole, minimally processed foods such as fruits, vegetables, proteins, and healthy fats. Limit consumption of refined carbohydrates, sugary foods, and beverages, which can contribute to insulin resistance.
Intermittent Fasting
The 16:8 schedule is fasting for 16 hours followed by an eight-hour eating window. Restricted calorie intake for extended period of time forces your body to break down fat to generate energy.
Low Glycemic Index Food
Here are the examples of low glycemic index food:
Non-starchy vegetables: Leafy greens, broccoli, cauliflower, asparagus, peppers, mushrooms.
Fruits : Berries, apples, pears, grapefruits, oranges (with fiber).
Whole grains: Oats, barley, brown rice, quinoa, bulgur wheat.
Legumes: Beans, lentils, chickpeas.
Nuts and seeds: Almonds, walnuts, chia seeds, flaxseeds.
Low-fat dairy: Greek yogurt, kefir.
In general, high fiber content food has low glycemic index while refined carbohydrates like white bread have a high glycemic index.
Supplements
Berberine may enhance insulin signaling and influence how insulin receptors on cells function, making them more responsive to insulin's message to take in glucose.
Berberine can activate an enzyme called AMP-activated protein kinase (AMPK), which plays a key role in cellular energy metabolism. AMPK activation can improve insulin sensitivity in various tissues.
Magnesium plays an important role in glucose metabolism and insulin sensitivity. Studies shows that magnesium was associated with healthy heart function and better glucose utilization. Magnesium supplement can significantly help reduce insulin resistance and improve glycemic control.
Regular Exercise
Physical activity is one of the most effective ways to increase insulin sensitivity. Aim for at least 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous-intensity exercise per week, along with muscle-strengthening activities on two or more days per week.
Hydration
Staying well-hydrated by drinking water throughout the day may help improve insulin sensitivity. Avoid sugary beverages and excessive caffeine intake, which can negatively impact blood sugar regulation.
Maintain a Healthy Weight
Excess body weight, especially in the abdominal area, is strongly associated with insulin resistance. Losing weight, if overweight or obese, can improve insulin sensitivity. Even modest weight loss of 5-10% of body weight can have significant benefits.
Stress Management
Chronic stress can contribute to insulin resistance and metabolic dysfunction. Practice stress-reducing techniques such as mindfulness meditation, deep breathing exercises, yoga.
Adequate Sleep
Poor sleep quality and insufficient sleep duration have been linked to insulin resistance and increased risk of type 2 diabetes. Aim for 7-9 hours of quality sleep per night to support metabolic health.
Limit Alcohol Consumption
Excessive alcohol intake can impair insulin sensitivity and contribute to insulin resistance. If you choose to drink alcohol, do so in moderation and consider opting for lower-sugar options.
If you find this information helpful, please share with your friends and family who may benefit from this information.
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References
Bédard S, Marcotte B, Marette A. Insulin inhibits inducible nitric oxide synthase in skeletal muscle cells. Diabetologia. 1998 Dec;41(12):1523-7.
Feng X & et al. Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics. 2019 Mar 16;9(7):1923-1951.
He K & et al. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 2006 Apr 4;113(13):1675-82.
Landsberg L. Insulin and the sympathetic nervous system in the pathophysiology of hypertension. Blood Press Suppl. 1996;1:25-9.
Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun G. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015 Feb 23;161:69-81.
Magenta A, Greco S, Capogrossi MC, Gaetano C, Martelli F. Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction. Biomed Res Int. 2014;2014:193095.
Su Q, Huang J, Chen X, Wang Y, Shao M, Yan H, Chen C, Ren H, Zhang F, Ni Y, Jose PA, Zhong J, Yang J. Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway. Mol Nutr Food Res. 2023 Apr;67(7):e2200589.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.