# 1 Vitamin For Systemic Lupus Erythematosus
A Must Have Vitamin For Lupus
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by immune system attacks healthy organs throughout the body. This can affect the skin, joints, kidneys, heart, lungs, brain, and blood cells.
The exact cause of lupus is not known. Symptoms include fever, fatigue, muscle or joint pain, facial butterfly erythema, photosensitivity, arthritis and impaired kidneys function.
Current treatments include corticosteroids, immunosuppressants, anti-malaria and anti-inflammatory drugs to control symptoms and prevent flare-ups. However, the side effect profile of these medications could be undesirable for long-term use.
Vitamin D
Vitamin D is a powerful anti-inflammatory agent and plays a crucial role in the immune system especially for people who have systemic lupus erythematosus (SLE).
Vitamin D receptors (VDR) can be found in different white blood cells such as T cells, macrophages and dendritic cells which play a key role in modulating immune response, inflammation, immune tolerance or defense against pathogens.
Immune tolerance is critical for the immune system to recognize and tolerate as “self” tissue while mounting appropriate responses against “non-self” or pathogens. Failure of immune tolerance can lead to autoimmune disease in which the immune system mistakenly attacks its own self tissue.
Vitamin D can modulate the function of various immune cells, including T cells, B cells, and antigen-presenting cells like macrophages and dendritic cells. It helps regulate the balance between pro-inflammatory and anti-inflammatory responses, which is crucial for maintaining immune system balance and preventing excessive inflammation.
Vitamin D can suppress the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), while promoting the production of anti-inflammatory cytokines. Vitamins D helps prevent excessive inflammation, which is associated with autoimmune diseases and chronic inflammatory conditions.
A large cross-sectional study with 290 SLE patients were conducted to determine if there was a relationship between vitamin D deficiency and SLE. The study showed that 277 patients had a 25-hydroxy vitamin D insufficiency (< 30 ng/ml) and 77 patients had a critically low 25-hydroxy vitamin D (<15 ng/ml).
Another cohort study with 165 SLE patients and 214 non-SLE volunteers in Saudi Arabia showed that the prevalence of vitamin D deficiency was higher in the SLE group versus the non-SLE group.
A cohort study with 35 SLE children in Taiwan showed that low vitamin D levels was associated with SLE.
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References
Ao T, Kikuta J, Ishii M. The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules. 2021 Nov 3;11(11):1624.
Cheng KH, Tsai MC, Fu LS. The correlation between VitD3 levels and the disease activity of childhood-onset systemic lupus erythematosus. J Chin Med Assoc. 2022 May 1;85(5):627-632.
Damanhouri LH. Vitamin D deficiency in Saudi patients with systemic lupus erythematosus. Saudi Med J. 2009 Oct;30(10):1291-5.
Lin TC, Wu JY, Kuo ML, Ou LS, Yeh KW, Huang JL. Correlation between disease activity of pediatric-onset systemic lupus erythematosus and level of vitamin D in Taiwan: A case-cohort study. J Microbiol Immunol Infect. 2018 Feb;51(1):110-114.
Lee WL, Lee FK, Wang PH. Vitamin D and systemic lupus erythematous. J Chin Med Assoc. 2022 Aug 1;85(8):811-812.
Mok CC, Birmingham DJ, Leung HW, Hebert LA, Song H, Rovin BH. Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis. Rheumatology (Oxford). 2012 Apr;51(4):644-52.
Stagi S, Rigante D. Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues. Autoimmun Rev. 2018 Mar;17(3):290-300.
Watad A, Neumann SG, Soriano A, Amital H, Shoenfeld Y. Vitamin D and Systemic Lupus Erythematosus: Myth or Reality? Isr Med Assoc J. 2016 Mar-Apr;18(3-4):177-82.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.